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Dr. Ho-Leung Fung, Ph.D., FAAPS

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New AAPS Journal article of possible community interest

Machine Learning Prediction of Clinical Trial Operational Efficiency - The AAPS Journal SpringerLink remove preview Machine Learning Prediction of Clinical Trial Operational Efficiency - The AAPS Journal Clinical trials are the gatekeepers and bottlenecks of progress ...

New AAPS Journal article of possible community interest

Cluster Gauss-Newton and CellNOpt Parameter Estimation in a Small Protein Signaling Network of Vorinostat and Bortezomib Pharmacodynamics - The AAPS Journal The AAPS Journal remove preview Cluster Gauss-Newton and CellNOpt Parameter Estimation in a Small Protein Signaling ...

New AAPS Journal article of possible community interest

Quantitative Systems Pharmacology Modeling of Avadomide-Induced Neutropenia Enables Virtual Clinical Dose and Schedule Finding Studies - The AAPS Journal The AAPS Journal remove preview Quantitative Systems Pharmacology Modeling of Avadomide-Induced Neutropenia Enables ...

New AAPS Journal article of possible community interest

Network-Based Systems Analysis Explains Sequence-Dependent Synergism of Bortezomib and Vorinostat in Multiple Myeloma - The AAPS Journal The AAPS Journal remove preview Network-Based Systems Analysis Explains Sequence-Dependent Synergism of Bortezomib and Vorinostat in ...

New AAPS Journal article of possible community interest

The Evolution of Single-Cell Analysis and Utility in Drug Development - The AAPS Journal The AAPS Journal remove preview The Evolution of Single-Cell Analysis and Utility in Drug Development - The AAPS Journal This review provides a brief history of the advances of ...

New AAPS Journal article of possible community interest

Developing Tools to Evaluate Non-linear Mixed Effect Models: 20 Years on the npde Adventure The AAPS Journal remove preview Developing Tools to Evaluate Non-linear Mixed Effect Models: 20 Years on the npde Adventure This article revisits 20 years of our work in developing ...

New AAPS Journal article of possible community interest

FDA-Industry Scientific Exchange on assessing quantitative systems pharmacology models in clinical drug development: a meeting report, summary of challenges/gaps, and future perspective The AAPS Journal remove preview FDA-Industry Scientific Exchange on assessing quantitative ...

New AAPS Journal article of possible community interest

A Systematic Review of the Efforts and Hindrances of Modeling and Simulation of CAR T-cell Therapy The AAPS Journal remove preview A Systematic Review of the Efforts and Hindrances of Modeling and Simulation of CAR T-cell Therapy Chimeric antigen receptor (CAR) T-cell ...

New AAPS Journal article of possible community interest

An Item Response Theory-Informed Strategy to Model Total Score Data from Composite Scales The AAPS Journal remove preview An Item Response Theory-Informed Strategy to Model Total Score Data from Composite Scales Composite scale data is widely used in many therapeutic ...

New AAPS Journal article of possible community interest

Bounded Integer Modeling of Symptom Scales Specific to Lower Urinary Tract Symptoms Secondary to Benign Prostatic Hyperplasia The AAPS Journal remove preview Bounded Integer Modeling of Symptom Scales Specific to Lower Urinary Tract Symptoms Secondary to Benign Prostatic ...

New AAPS Journal article of possible community interest

Multiscale and Translational Quantitative Systems Toxicology, Pharmacokinetic-Toxicodynamic Modeling Analysis for Assessment of Doxorubicin-Induced Cardiotoxicity The AAPS Journal remove preview Multiscale and Translational Quantitative Systems Toxicology, Pharmacokinetic-Toxicodynamic ...

New publication in The AAPS Journal of possible community interest

Comparison of Precision and Accuracy of Five Methods to Analyse Total Score Data The AAPS Journal remove preview Comparison of Precision and Accuracy of Five Methods to Analyse Total Score Data Total score (TS) data is generated from composite scales consisting of ...

New AAPS Journal article of possible community interest

Predicting Chemotherapy-Induced Neutropenia and Granulocyte Colony-Stimulating Factor Response Using Model-Based In Vitro to Clinical Translation The AAPS Journal remove preview Predicting Chemotherapy-Induced Neutropenia and Granulocyte Colony-Stimulating Factor Response ...

New AAPS Journal article of possible community interest

Demonstrating Contribution of Components of Fixed-Dose Drug Combinations Through Longitudinal Exposure-Response Analysis SpringerLink remove preview Demonstrating Contribution of Components of Fixed-Dose Drug Combinations Through Longitudinal Exposure-Response Analysis ...

New AAPS Journal article of possible community interest

Item Response Theory Modeling of the International Prostate Symptom Score in Patients with Lower Urinary Tract Symptoms Associated with Benign Prostatic Hyperplasia The AAPS Journal remove preview Item Response Theory Modeling of the International Prostate Symptom Score ...

New AAPS Journal article of possible community interest

Challenge-Enabled Machine Learning to Drug-Response Prediction The AAPS Journal remove preview Challenge-Enabled Machine Learning to Drug-Response Prediction In recent decades, the advancement of computational algorithms and the availability of big data have enabled ...

New AAPS Journal article of possible community interest

Application of Beta-Distribution and Combined Uniform and Binomial Methods in Longitudinal Modeling of Bounded Outcome Score Data The AAPS Journal remove preview Application of Beta-Distribution and Combined Uniform and Binomial Methods in Longitudinal Modeling of Bounded ...

New AAPS Journal article of possible community interest

Considerations and Caveats when Applying Global Sensitivity Analysis Methods to Physiologically Based Pharmacokinetic Models The AAPS Journal remove preview Considerations and Caveats when Applying Global Sensitivity Analysis Methods to Physiologically Based Pharmacokinetic ...

New AAPS Journal article of possible community interest

Integrated Item Response Theory Modeling of Multiple Patient-Reported Outcomes Assessing Lower Urinary Tract Symptoms Associated with Benign Prostatic Hyperplasia The AAPS Journal remove preview Integrated Item Response Theory Modeling of Multiple Patient-Reported Outcomes ...

New AAPS Journal article of possible community interest

Saddle-Reset for Robust Parameter Estimation and Identifiability Analysis of Nonlinear Mixed Effects Models The AAPS Journal remove preview Saddle-Reset for Robust Parameter Estimation and Identifiability Analysis of Nonlinear Mixed Effects Models Parameter estimation ...