AAPS Webinar: Lipid Nanoparticle-Based Endogenous Targeted Delivery of Nucleic Acid Therapeutics

Significant advances in nucleic acid therapeutics, including the use of mRNA vaccines for COVID-19, have spurred new interest in the use of lipid nanoparticles (LNPs) especially for extrahepatic delivery. In this presentation, I will cover our work on utilizing endogenous mechanisms for targeted delivery of nucleic acid therapeutics. Specifically, I will cover on the role of protein corona formed on LNPs, myeloid cell uptake of LNPs and selective tropism towards disease sites, and secretion of extracellular vesicles and their ability to amplify transfection through a bystander effect.

Learning Objectives:

• Specific approaches for targeted nucleic acid delivery using lipid nanoparticles (LPNs) and specific emphasis on endogenous mechanisms.
• The role of tailored protein corona composition on LNPs and potential for extrahepatic delivery.
• Using myeloid cells as Trojan Horse in LNP-mediated transfection and therapeutic benefits for treatment of inflammation and cancer.