Join us Thursday, April 20 from noon to 1 pm EST for an Open Scientific Discussion:
Differential Surface Adsorption Phenomena for Conventional and Novel Surfactants Correlates with Changes in Interfacial mAb Stabilization
Ankit Kanthe, Formulation and Analytical Scientist, Bristol Myers Squibb
The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.2c00152.
Langmuir adsorption isotherm fit to determine cmc and maximum surface coverage for PS80 and FM1000; X-ray reflectivity data analysis; surface concentration calculations for single component (mAb or PS80 orFM1000) and mixed component (mAb + PS80 or mAb + FM1000); homology modeling along with the estimate for mAb size; XRR profile with the corresponding EDP for pure PS80, pure FM1000, mAb + PS80, and mAb + FM1000; and overlapping XRR measurements to compare the mixed component system alongside the pure mAb and pure surfactant XRR data (PDF)
@Ankit Kanthe @Miriam Carnovale @Joshua Katz @Susan Jordan @Mary Krause @Songyan Zheng @Andrew Ilott @William Ying @Wei Bu @Mrinal Bera @Binhua Lin @Raymond Tu @Charles Maldarelli
Cohosted by the Excipients and the Biopharmaceutical Product Attributes and Biological Consequences (BPABC) Communities
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Allison Radwick Ph.D.
Sr Regulatory & Policy Comms Mgr
USP
Rockville MD
[email protected]
Disclaimer: Opinions expressed are solely my own and do not express the views or opinions of my employer.
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