This presentation will focus on the use of equivalence testing as opposed to difference testing for the demonstration of mean comparability for two processes. Although both approaches are performed by constructing a confidence interval on the average difference, the hypotheses being testing are quite different. The presentation will demonstrate these differences through an application used to determine if the accuracy of two analytical procedures can be considered comparable. Presentations on “what is a p-value?” and “What is a confidence interval?” should be viewed before this video for ease of understanding.
This video is part of an educational series presented by AAPS. Stats Snax discusses basic statistical concepts that apply to the pharmaceutical industry using examples from CMC development areas. Designed for non-statisticians, you will learn foundational concepts that CMC statisticians encounter in their daily interactions with clients. If you have ever wondered, “What is a p-value?” or “How is expiry determined?” – This series is for you!