Oral delivery of biologics presents many obstacles towards successful administration. One route, buccal delivery through microneedle arrays (MN) offers a potential solution to such difficulties. However, MNs of sufficient type and characteristics for buccal delivery generally face limited drug load capacity due to solubility issues in polymer and other matrices. In this paper by Cafferal-Salvador, a novel MN platform with high drug load capacity, and rapid release of human growth hormone or insulin in swine is discussed. Additionally, said MNs were evaluated and tested for optimal placement for minimal discomfort in human patients.