eChalk Talk: New Software Tools for Impurity Analysis of Synthetic Oligonucleotides

When:  Sep 7, 2022 from 13:15 to 13:45 (ET)
Associated with  AAPS Community

Oligonucleotide therapeutics have emerged in recent years as a powerful alternative to small molecule and protein therapeutics. Manufacturing and quality control of oligonucleotide therapeutics requires highly selective and sensitive LC-MS methods. This presentation will highlight two recently introduced software applications: one used for purity analysis and rapid intact mass confirmation of oligonucleotide impurities, the second one for fast data interpretation of complex oligonucleotide fragmentation spectra. These two applications are embedded in an automated, compliance-ready LC-MS workflow designed for analysis of synthetic oligonucleotides and their impurities.


Catalin Doneanu received his Ph.D. in analytical chemistry from Oregon State University in 2002. After a postdoctoral stage in the Department of Medicinal Chemistry at University of Washington in Seattle, he joined Waters Corporation in 2006. He is currently a principal scientist in the Biopharmaceutical Sciences group. He has more than twenty years of experience in separation sciences and mass spectrometry. His current research interests are in the area of therapeutic oligonucleotides and protein characterization using LC-MS. Catalin has over 30 peer-reviewed publications.


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