Please join us for an Open Scientific Discussion (OSD) hosted by the AAPS Gene and Cell Therapy Product (GCTP), Biomarkers and Precision Medicine (BPM) and BioAnalytical (BA) Communities on July 25, 2023, 12 pm – 1 pm EDT on the following topic:
Detection and Quantification of On- and Off-target Genome Editing Events for Gene and Cell Therapy Drug Development
· What is the workflow of detecting off-target genome editing activities during preclinical and clinical studies?
· What are the different unbiased and targeted methodologies to detect on- and off-target genome editing outcomes?
· What are the critical analytical parameters when quantifying on-target and validated off-target editing frequencies during clinical studies?
Discussion Leaders:
Yanmei Lu (Sangamo Therapeutics), Ling Lin (Beam Therapeutics) and Cicera Lazzarotto (Beam Therapeutics)
Organized by:
Yanmei Lu (Sangamo Therapeutics), Priya Chockalingam (Beam Therapeutics), Yan Ni (Passage Bio), Carmen Fernández-Metzler (PharmaCadence), Karen Quadrini (Passage Bio), and Sanjeev Bhardwaj (Moderna)
We start at 12:00 EDT sharp. To avoid interruptions, please dial in before noon and mute yourself until Q&A starts.
(Please remain on mute unless asking questions)
When: Tuesday, July 25, 2023, 12 pm – 1 pm EDT
Where: Please join from your computer, tablet or smartphone.
https://global.gotomeeting.com/join/305789893
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United States: +1 (872) 240-3412
Access Code: 305-789-893
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Dial in or type: 67.217.95.2 or inroomlink.goto.com
Meeting ID: 305 789 893
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Please feel free to share with colleagues who may be interested in this topic.
Thank you,
The Leadership Teams of the AAPS GCTP, BPM and BA Communities
#OpenScientificDiscussions#OSD#CellGeneTherapy#Biomarkers#biomarker