In Vitro Release and Dissolution Testing Community (IVRDTC)

Dear community members

As we gear to finalize topics for webinars from our community, team members have proposed below topics. The topics are consistent with goal of the community for 2025. 

1. Alcohol dose dumping complexities and harmonization of Pharmacopeial requirements
2. Biorelevant dissolution media/ testing
3. AI/ ML in dissolution testing 

Please free to add your comments or suggestions for potential topics/ suggested speakers.

Thank you and have a great holiday season ahead. Merry Christmas and happy holidays! 

Webinar Topic: Sustainability in Dissolution Testing: Reducing Waste and Environmental Impact Through Green Chemistry Approaches

Overview : The pharmaceutical industry is increasingly focusing on sustainability to minimize its environmental footprint. Dissolution testing, a critical process in drug development and quality control, generates significant waste due to the use of solvents, reagents, and single-use materials. This webinar will explore how adopting green chemistry principles can reduce waste and environmental impact while maintaining the rigor and reliability of dissolution testing methods.

Key Discussion Points

1. Environmental Challenges in Dissolution Testing

   • High consumption of organic solvents and reagents.
   • Generation of hazardous waste requiring costly disposal.
   • Energy-intensive processes contributing to carbon emissions.

2. Principles of Green Chemistry in Dissolution Testing

   • Designing solvent-free or low-solvent methods.
   • Using biodegradable and non-toxic dissolution media.
   • Implementing energy-efficient instrumentation.

3. Sustainable Solutions for Reducing Waste

   • Recycling and reusing dissolution media and testing materials.
   • Development of miniaturized testing methods to reduce sample and solvent volumes.
   • Adopting automation and high-throughput techniques for efficiency.

4. Advancements in Green Dissolution Technologies

   • Use of supercritical fluids as eco-friendly solvents.
   • Application of water-based media for dissolution of poorly soluble drugs.
   • Integration of in silico modeling to reduce experimental iterations.

5. Regulatory and Industry Perspectives

   • Alignment with sustainability goals set by regulatory agencies and global initiatives.
   • Challenges in adopting green practices within existing regulatory frameworks.

6. Case Studies and Success Stories

   • Examples of companies implementing green dissolution practices.
   • Quantifiable benefits: reduced waste, lower costs, and improved environmental compliance.

Dear community members

As we gear to finalize topics for webinars from our community, team members have proposed below topics. The topics are consistent with goal of the community for 2025. 

1. Alcohol dose dumping complexities and harmonization of Pharmacopeial requirements
2. Biorelevant dissolution media/ testing
3. AI/ ML in dissolution testing 

Please free to add your comments or suggestions for potential topics/ suggested speakers.

Thank you and have a great holiday season ahead. Merry Christmas and happy holidays!