Topical and Transdermal Community

Join Dr. Banga from Mercer University for his webinar on "Multifaceted consideration to pick the right technology to get your drug under my skin ! at AAPS platform moderated by Modified Release Community

Date: Tuesday, July 26, 2022
Time: 9:30 AM PDT / 10:30 AM MDT / 11:30 AM CDT / 12:30 PM EDT

If not registered, click the link below for a few webinar

https://lnkd.in/geJ6f5vA


Moderately lipophilic small potent drugs can passively diffuse into skin, with or without chemical enhancers, in sufficient quantity to reach therapeutic dose. On the other hand, hydrophilic macromolecules need delivery assisted by some means such as iontophoresis or skin microporation. These technologies face different types of challenges. For example, iontophoresis is limited to deliver molecules up to around 13kDa and may potentially induce skin burns if skin contact is not uniform. Sonophoresis and laser-based devices may face challenges to miniaturize the device for home use by patients. Potential dose dumping or other failure of drug-device combination is possible. Microneedles offer a pragmatic skin microporation approach that can be developed into a small patch, with minimal risk of drug-device combination failure. A particulate formulation can be used for preferential follicular uptake, or to release the drug to skin surface in a controlled manner. This presentation will discuss the scientific, pragmatic and regulatory considerations that will dictate the choice of appropriate technology to deliver a pharmaceutical or cosmetic molecule into or across the skin.

#modifiedrelease #drugdelivery #topical #transdermal  #iontophoresis # #webinar #pharmaceutical #sonophoresis #microneedles #gel #aaps #modifiedreleasecommunity

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Sowmya Kulal
Senior Scientist, Sterile Formulation Dev
Alcami Corporation
Morrisville NC
[email protected]

Disclaimer: Opinions expressed are solely my own and do not express the views or opinions of my employer.
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