Bioanalytical Community

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  • 1.  Volunteers sought for Bioanalytical 101 Course

    Community Leadership
    Posted 07-25-2023 15:51

    As we continue towards a free eCourse for Bioanalytical 101, the team is seeking additional volunteers to support module 3 on chromatographic methods and module 4 ligand-binding assays. If interested, please contact @Ankur Patel or @Joleen White in general or @Sanjeev Bhardwaj for module 3 and @Linglong Zou for module 4.



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    Joleen White Ph.D.
    AAPS 2023 Global Health Community Past Chair
    Bioanalytical 101 Course Development
    Head of Bioassay Development
    Gates Medical Research Institute
    Cambridge MA
    [email protected]

    Disclaimer: Opinions expressed are solely my own and do not express the views or opinions of my employer.
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  • 2.  RE: Volunteers sought for Bioanalytical 101 Course

    Posted 07-26-2023 09:04

    What are the timelines?

     

    Ty, hm

     

    Heather Myler, Ph.D.

    Senior Director, Head of Immunogenicity and New Modalities

    Bioanalytical and Biomarker Sciences and Technologies CoE

     

    Takeda Development Center Americas, Ltd.

    35 Landsdowne St.

    Cambridge, MA 02139

    U.S.A

    Cell: 818-519-3561

    [email protected]

     

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    Original Message


  • 3.  RE: Volunteers sought for Bioanalytical 101 Course

    Community Leadership
    Posted 07-26-2023 10:03

    I'm happy to help edit/advise but can't commit the time to writing at this time.



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    Chad Briscoe PhD
    VP of Global Bioanalytical Labs
    Celerion
    Lincoln NE
    [email protected]

    Disclaimer: Opinions expressed are solely my own and do not express the views or opinions of my employer.
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    Original Message


  • 4.  RE: Volunteers sought for Bioanalytical 101 Course

    Posted 07-27-2023 15:40

    All - We had a great response from our BA community members and thus were able to easily find the additional volunteers.  

    @Heather Myler

    We are in the planning and organizing responsibilities for module 3 so timelines are a little flexible.

    @Chad Briscoe

    Thanks for the offer of help with the editing/advising.  I will reach out to you when we get to the final stages.

    I also saw some queries about the Module 3 content so am including the outline of Module 3 below:

    Module 3 Chromatographic Methods for Bioanalysis

    3.1 Principles of Chromatography

    1. First principles: Polarity, Hydrophobicity, Sterics

    2. Stationary Phases

    3. Mobile Phases

    4. Best Practices

    5. Detection methods (including brief MS intro)

    3.2 Principles of Mass Spectrometry

    1. Ionization - Positive and Negative

    2. Impact of solvents - volatility, counterions

    3. Fragmentation - Parents/Daughters; precursors/products

    4. MRM, SRM, PRM, HRMS

    5. Accelerated MS (ADME)

    6. Affinity selection MS

    7. Best Practices

    3.3 Special considerations for LC/MS/MS

    1. Internal Standards - purpose, monitoring, stable labelled

    2. Suppression & Matrix Factor

    3. Interference testing 

    3.4 Mass spec not just for small molecules

    1. Mass spec - intact vs mid down vs bottom up - immunoprecipitation goes here

    2. Proteins, Peptides

    3. Oligonucleotides in the middle

    4. ADCs

    Please reach out to me in case of questions @Sanjeev Bhardwaj

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    Original Message