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Upcoming OSD Tues, July 25th: Detection and Quantification of On- and Off-target Genome Editing Events for Gene and Cell Therapy Drug Development

  • 1.  Upcoming OSD Tues, July 25th: Detection and Quantification of On- and Off-target Genome Editing Events for Gene and Cell Therapy Drug Development

    Community Leadership
    Posted 07-17-2023 08:20

    Please join us for an Open Scientific Discussion (OSD) hosted by the AAPS Gene and Cell Therapy Product (GCTP), Biomarkers and Precision Medicine (BPM) and BioAnalytical (BA) Communities on July 25, 2023, 12 pm – 1 pm EDT on the following topic:

    Detection and Quantification of On- and Off-target Genome Editing Events for Gene and Cell Therapy Drug Development

    ·       What is the workflow of detecting off-target genome editing activities during preclinical and clinical studies?

    ·       What are the different unbiased and targeted methodologies to detect on- and off-target genome editing outcomes?

    ·       What are the critical analytical parameters when quantifying on-target and validated off-target editing frequencies during clinical studies?

    Discussion Leaders:

    Yanmei Lu (Sangamo Therapeutics), Ling Lin (Beam Therapeutics) and Cicera Lazzarotto (Beam Therapeutics)

    Organized by:  

    Yanmei Lu (Sangamo Therapeutics), Priya Chockalingam (Beam Therapeutics), Yan Ni (Passage Bio), Carmen Fernández-Metzler (PharmaCadence), Karen Quadrini (Passage Bio), and Sanjeev Bhardwaj (Moderna)

    We start at 12:00 EDT sharp. To avoid interruptions, please dial in before noon and mute yourself until Q&A starts.

    (Please remain on mute unless asking questions) 

    When: Tuesday, July 25, 2023, 12 pm – 1 pm EDT

    Where: Please join from your computer, tablet or smartphone.
    https://global.gotomeeting.com/join/305789893

    You can also dial in using your phone.
    United States:     +1 (872) 240-3412
    Access Code: 305-789-893

    Join from a video-conferencing room or system.
    Dial in or type:     67.217.95.2 or inroomlink.goto.com
    Meeting ID: 305 789 893
    Or dial directly:     [email protected] or 67.217.95.2##305789893

    New to GoToMeeting? Get the app now and be ready when your first meeting starts:
    https://global.gotomeeting.com/install/305789893

     

    Please feel free to share with colleagues who may be interested in this topic.

     

    Thank you,

    The Leadership Teams of the AAPS GCTP, BPM and BA Communities

    #OpenScientificDiscussions #OSD #CellGeneTherapy #Bioanalytical #Biomarkers 



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    Karen Quadrini, PhD
    Director, Biomarkers and Precision Medicine
    Passage Bio
    Philadelphia, PA
    [email protected]

    Disclaimer: Opinions expressed are solely my own and do not express the views or opinions of my employer.
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