AAPS Modified Release Community Webinar
Tuesday, March 25th, 1.00 - 2:00 PM EST
https://oklahoma.zoom.us/meeting/register/Za4WUcf2SsecULmf-pKsEg
Michael J Cima, PhD, David H. Koch Professor of Engineering, Massachusetts Institute of Technology
Therapy and measurement in single compartments
Abstract: Compartments such as the ureter, bladder, peritoneum, and brain are often sites of disease and can sometimes be viewed as "privileged," since they intrinsically hinder partitioning of systemically administered agents and segregate important diagnostic analytes. Drug design is built on the concept that key molecular targets of disease are isolated in the diseased tissue. Systemic drug administration would be sufficient for targeting in such a case. It is, however, common for enzymes or receptors that are integral to disease to be structurally similar or identical to those that play important biological roles in normal tissues of the body. Additionally, systemic administration may not lead to local drug concentrations high enough to yield disease modification because of rapid systemic metabolism or lack of sufficient partitioning into the diseased tissue compartment. This talk discusses several methods that physically target drugs and enhance measurements to individual compartments of the body. These compartments have become the focus of a wide array of procedures and devices for direct administration of drugs and diagnostic procedures. The rationale behind single compartment drug delivery or measurement is briefly discussed as well as the results of several clinical trials.
Thank you,
Vibhuti
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Vibhuti Agrahari Ph.D.
Assistant Professor
University of Oklahoma
Oklahoma City OK
[email protected]Disclaimer: Opinions expressed are solely my own and do not express the views or opinions of my employer.
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