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The Effects of Excipients on Freeze-dried Monoclonal Antibody Formulation Degradation and Sub-Visible Particle Formation during Shaking

  • 1.  The Effects of Excipients on Freeze-dried Monoclonal Antibody Formulation Degradation and Sub-Visible Particle Formation during Shaking

    Community Leadership
    Posted 02-05-2024 16:41

    Contrary to the common beliefs, authors show that shaking stress could cause protein degradation in freeze-dried monoclonal antibody (mAb) formulations. Specifically, the effects of shaking stress on protein degradation and sub-visible particle formation in freeze-dried mAb formulations is investigated.

    The Effects of Excipients on Freeze-dried Monoclonal Antibody Formulation Degradation and Sub-Visible Particle Formation during Shaking | Pharmaceutical Research (springer.com)



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    Suman Luthra
    Director
    Merck
    Boston MA
    [email protected]

    Disclaimer: Opinions expressed are solely my own and do not express the views or opinions of my employer.
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  • 2.  RE: The Effects of Excipients on Freeze-dried Monoclonal Antibody Formulation Degradation and Sub-Visible Particle Formation during Shaking

    Community Leadership
    Posted 02-07-2024 18:41

    We can't get a break from particles! 

    Thanks for posting. 



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    Tapan Das, Ph.D., FAAPS


    Disclaimer: Opinions expressed are solely my own and do not express the views or opinions of my employer
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    Original Message