Pharmacokinetics, Pharmacodynamics, & Drug Metabolism Community

This message was posted by a user wishing to remain anonymous

Dear All,

I have come up with the following questions that want to get some inspirations:

1. How will Gastric bypass surgery impact the absorption of GLP-1 Receptor agonist drug?
2. Will taking statins or metformin impact GLP-1 Receptor agonist drugs' PK/PD outcomes (DDI)?
3. How will PBPK modeling help to address this issue?

Thank you!

What You Need to Know About Using PBPK Modeling for DDI Interaction Assessments for GLP-1 Agonists - Simulations Plus

Hi,

Check out this exciting blog for the utility of PBPK modeling in this domain. 

Thanks,

------------------------------
Saima Subhani
Scientist
Simulations-Plus
Lansdale PA
[email protected]

Disclaimer: Opinions expressed are solely my own and do not express the views or opinions of my employer.
------------------------------

Original Message:
Sent: 10-08-2024 16:40
From: Anonymous Member
Subject: Question about GLP-1 Receptor agonist drug

This message was posted by a user wishing to remain anonymous

Dear All,

I have come up with the following questions that want to get some inspirations:

1. How will Gastric bypass surgery impact the absorption of GLP-1 Receptor agonist drug?
2. Will taking statins or metformin impact GLP-1 Receptor agonist drugs' PK/PD outcomes (DDI)?
3. How will PBPK modeling help to address this issue?

Thank you!

Hi

Eli Lilly scientists have already used PBPK modelling to address Dulaglutide-mediated gastric emptying delay for few drugs including statins and saved several clinical studies. Their presentation can be found here: https://youtu.be/Wgla50ofnI8. 

PBPK modelling is also used for modelling various types of bariatric surgeries, please see:

PBPK Modeling of Azithromycin Systemic Exposure in a Roux-en-Y Gastric Bypass Surgery Patient Population. 

Impact of obesity and roux‐en‐Y gastric bypass on the pharmacokinetics of (R)‐ and (S)‐omeprazole and intragastric pH - Pippa - 2024 - CPT: Pharmacometrics & Systems Pharmacology - Wiley Online Library

Regards 
Masoud 

------------------------------
Masoud Jamei Ph.D., FAAPS
SVP of R&D
Certara UK (Simcyp Division)
Sheffield
[email protected]

Disclaimer: Opinions expressed are solely my own and do not express the views or opinions of my employer.
------------------------------

Original Message:
Sent: 10-08-2024 16:40
From: Anonymous Member
Subject: Question about GLP-1 Receptor agonist drug

This message was posted by a user wishing to remain anonymous

Dear All,

I have come up with the following questions that want to get some inspirations:

1. How will Gastric bypass surgery impact the absorption of GLP-1 Receptor agonist drug?
2. Will taking statins or metformin impact GLP-1 Receptor agonist drugs' PK/PD outcomes (DDI)?
3. How will PBPK modeling help to address this issue?

Thank you!