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Purity Best Practices for Reference Standards

  • 1.  Purity Best Practices for Reference Standards

    Posted 03-27-2024 09:51

    I am interested in getting input from a variety of contributors to see if internal best practices are following those used in the wider community. 

    For small molecule bioanalysis, given a certificate of analysis that provides a variety of purity information, which do you consider the "true" purity for your PK assays? For example, if a certificate provides HPLC area % purity plus KF, plus residual metals as well as qNMR wt/wt % purity, do you calculate a purity from the first 3 or simply accept the qNMR value as truth?

    Thanks!



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    Jennifer Vance Ph.D.
    Dir. of Bioanalytical and Biomarker Development
    AIT Bioscience
    Greenwood IN
    [email protected]

    Disclaimer: Opinions expressed are solely my own and do not express the views or opinions of my employer.
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