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  • 1.  Primary reference standard container for biologics

    This message was posted by a user wishing to remain anonymous
    Posted 04-20-2023 09:14
    This message was posted by a user wishing to remain anonymous

    We are evaluating options for selecting containers to store primary reference standard material for a large molecule product with will be stored at -70°C.  I have used polypropylene cryovials in the past, but am curious if there are any other suitable options.





  • 2.  RE: Primary reference standard container for biologics

    AAPS Staff
    Posted 04-21-2023 07:29

    It depends on the molecule. Many cryovials for -70 are glass, but molecule adsorption (especially with proteins) is a concern. With polypropylene the long term performance of the vials in very low temperatures is of concern, so it is worth thinking about the lifespan of your primary material until replacement.



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    Tina Morris Ph.D.
    Executive Director
    AAPS
    Arlington VA
    [email protected]

    Disclaimer: Opinions expressed are solely my own and do not express the views or opinions of my employer.
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    Original Message


  • 3.  RE: Primary reference standard container for biologics

    Community Leadership
    Posted 04-26-2023 18:13

    Hi OP, This question can be posted on the Bioanalytical Community for additional input. 



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    Disclaimer: Opinions expressed are solely my own and do not express the views or opinions of my employer.
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    Original Message