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Prediction of surfactant-mediated dissolution of poorly soluble drugs from drug powder

  • 1.  Prediction of surfactant-mediated dissolution of poorly soluble drugs from drug powder

    Posted 05-15-2025 12:46

    I'm excited to share our recent work published in the European Journal of Pharmaceutical Sciences:

    "Prediction of surfactant-mediated dissolution of poorly soluble drugs from drug powder"
    📄 Roshni P. Patel, Erik B. Nordquist, James E. Polli
    🔗 https://doi.org/10.1016/j.ejps.2025.107052

    It is about predicting in vitro dissolution of poorly water-soluble drugs in surfactant media. Using a particle size distribution-based film model and two competing diffusion layer thickness approaches (fixed vs. radius-dependent), we successfully predicted dissolution profiles of posaconazole, ritonavir, and griseofulvin in buffers and various surfactant solutions (SLS, PS80, POE10, CTAB).

    ✅ Highlights:

    • Accurate prediction using entire particle size distribution

    • Fixed diffusion layer thickness (12 µm) showed better predictive accuracy 

    Always happy to discuss more on particle dissolution prediction!



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    Roshni Patel
    PhD Student in Pharmaceutical Science
    University of Maryland At Baltimore
    Baltimore MD
    [email protected]

    Disclaimer: Opinions expressed are solely my own and do not express the views or opinions of my employer.
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