Please join the AAPS Bioanalytical Community on December 5th@ 12:00 pm EDT for an Open Scientific Discussion:
Current Strategies and Advancement in Quantitative Bioanalytical Oligonucleotide Methodologies
Oligonucleotides, which are nucleic-acid polymers that can range from ~10-50 base pairs, have been undergoing research and development as potential therapeutics for over three decades. Over that span of time, considerable advances have been made to increase the half-life of oligonucleotides via modifications and advances in drug delivery. Due to the advances being made in oligonucleotide development and delivery, expansion of oligonucleotide modalities, and increased volume of oligonucleotides being developed as therapeutics, an appropriate bioanalytical strategy must be implemented for the quantification of oligonucleotides. The importance of an appropriate bioanalytical strategy is amplified by the generated data being utilized to assess pharmacokinetic (PK) and drug metabolism (DM), as well as biodistribution. Current methodologies used extensively to quantitate oligonucleotides include chromatographic platforms, such as UPLC-UV, LC-FL, LC-MS/MS, and LC-HRAM, and ligand-binding assays (LBA) such as hybridization enzyme-linked immunosorbent assays (ELISA) and electrochemiluminescent (ECL) assays. Here we will discuss current strategies and advances in both chromatographic and ligand binding methodologies to quantitate oligonucleotides in pre-clinical and clinical studies and how they may be utilized to create a synergistic approach for oligonucleotide PK/DM assessments.
Moderator: Sanjeev Bhardwaj (Moderna)
Panel:
Long Yuan – Biogen
Eric Tewalt – PPD, part of Thermo Fisher Scientific
Troy Voelker – Aliri Bioanalysis
For more information, including calendar invites, and virtual meeting login info, please visit the EVENT PAGE. Admission is free, so invite your friends!
Have an idea for an upcoming session?
Please contact the OSD Committee Co-Chairs, @Sanjeev Bhardwaj & @Laurelle Calliste
We start at 12:00 EST sharp. Please dial in before noon to avoid interruptions and mute yourself until the Q&A starts.
You are encouraged to submit questions in the discussions section of the Bioanalytical Community Page prior to the event.
(Please remain on mute and submit your questions via the Chat feature of GoToMeeting)
Please join from your computer, Tablet, or smartphone.
https://meet.goto.com/BA-OSD
You can also dial in using your phone.
Access Code: 871-534-861
United States: +1 (571) 317-3122
Join from a video-conferencing room or system.
Meeting ID: 871-534-861
Dial in or type: 67.217.95.2 or inroomlink.goto.com
Or dial directly: [email protected] or 67.217.95.2##871534861
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#bioanalysis #Bioanalytical #OSD #OpenScientificDiscussions
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Sanjeev Bhardwaj
Moderna Therapeutics
Cambridge, MA.
[email protected]Disclaimer: Opinions expressed are solely my own and do not express the views or opinions of my employer.
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