Dr. Mallick, thank you for sharing your thoughts on OOC technology and its potential in toxicity testing and drug development. The application of OOC technology to create a blood-brain barrier on a chip (BBB-on-a-chip) is indeed an intriguing area of research with significant implications.
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Sejal Sharma
Research Assitant
Texas Tech University Health Sciences Center
Amarillo TX
[email protected]Disclaimer: Opinions expressed are solely my own and do not express the views or opinions of my employer.
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Original Message:
Sent: 05-31-2023 02:33
From: Pankajini Mallick
Subject: Organ-on-a-Chip
Thank you Sejal for this interesting question.
OOC technology represents a promising and innovative approach for toxicity testing and drug development. One area where OOC has been explored greatly is in drug metabolism to overcome the limitations of traditional in vitro cell culture systems in assessing chronic drug exposure and long-term effects on drug metabolism. For instance, liver-on-a-chip devices have been employed to investigate nonalcoholic fatty liver disease (NAFLD). However, it is important to note that the current physiological relevance of these culture systems is still somewhat limited. While OOC holds promise, it is still an evolving field and challenges remain in terms of achieving full organ complexity, long-term functionality, and scalability.
I am particularly interested in the application of OOC technology to create a blood-brain barrier on a chip (BBB-on-a-chip) and curious to hear from fellow members about their experiences on utility of BBB-on-a-chip and how it has been applied in their projects.
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Pankajini Mallick PhD
Principal Scientist, Preclinical Pharmacokinetics | DMPK
Neurocrine Biosciences
San Diego CA
Disclaimer: Opinions expressed are solely my own and do not express the views or opinions of my employer.
Original Message:
Sent: 05-29-2023 11:07
From: Sejal Sharma
Subject: Organ-on-a-Chip
Organ-on-a-Chip as a new paradigm for drug development, Any thoughts and/or experience?
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Sejal Sharma
Research Assitant
Texas Tech University Health Sciences Center
Amarillo TX
[email protected]
Disclaimer: Opinions expressed are solely my own and do not express the views or opinions of my employer.
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