Please join us for an Open Scientific Discussion (OSD) hosted by the AAPS Translational and Clinical Sciences Community on September 22, 12 pm – 1 pm EST on the following topic:
Best practices in the application of parallelism for biomarker assay validation
· Deep dive into the recent white paper, "Best practices in the application of parallelism for biomarker assay validation," published in the AAPS Journal (2026) 28:50 (https://doi.org/10.1208/s12248-025-01176-w)
· Understanding Parallelism: Key considerations for calibrators, surrogate matrices, and minimum required dilutions
· How and when to conduct and interpret parallelism experiments with confidence
· Expert strategies for evaluating parallelism throughout the assay lifecycle for both LBA and LC/MS platforms to ensure data reliability
o Including practical guidance on sample selection, data interpretation, specific considerations, and the application of acceptance criteria
Moderator:
· Shen, Honglue (Holly), Merck & Co., Inc. [email protected]
Carmen Fernandez-Metzler, PharmaCadence Analytical Services, LLC, [email protected]
Panelists:
· King, Lindsay Ewan, Pfizer [email protected]
· Barry Jones, Crinetics Pharmaceuticals [email protected]
Organizers:
· Holly Shen (Merck), Karen Quadrini (Prothena Biosciences), and Carmen Fernández-Metzler (PharmaCadence)
When: Tuesday, Sep 22, 2026 at 12 pm – 1 pm EST We start at 12:00 EST sharp.
Where: Free registration at https://science360.aaps.org/science360/2026/webinars/4235419
This OSD is open to all the scientific community and hosted through Science 360. The link above will take AAPS members directly to the OSD page. For non-members, the link will allow you to create a free account in order to join the OSD. There will be the possibility to ask questions live and submit questions.
Please feel free to share with everyone who may be interested in this topic.
Thanks,
On Behalf of The AAPS Translational and Clinical Biosciences Community Programming and Science Exchange Activity Team
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Carmen Fernandez-Metzler Ph.D.
President
PharmaCadence Analytical Services, LLC
Hatfield PA
[email protected]
Disclaimer: Opinions expressed are solely my own and do not express the views or opinions of my employer.
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