Modified Release Community

A Critical Overview of the Biological Effects of Excipients (Part I): Impact on Gastrointestinal Absorption - The AAPS Journal SpringerLink remove preview A Critical Overview of the Biological Effects of Excipients (Part I): Impact on Gastrointestinal Absorption - The AAPS Journal Traditionally, excipients have been considered in drug development from the perspective of their influence on drug solubility, manufacturability, and ability to control in vitro and in vivo drug release. These effects have been largely evaluated through studies involving in vitro dissolution methods. View this on SpringerLink >

A Critical Overview of the Biological Effects of Excipients (Part II): Scientific Considerations and Tools for Oral Product Development - The AAPS Journal SpringerLink remove preview A Critical Overview of the Biological Effects of Excipients (Part II): Scientific Considerations and Tools for Oral Product Development - The AAPS Journal It is now recognized that a number of excipients previously considered to be "inert" have the capacity to alter drug oral bioavailability through a range of in vivo effects. The various mechanisms through which an excipient can affect in vivo gastrointestinal physiology and drug absorption characteristics were explored in "A Critical Overview of The Biological Effects of Excipients (Part I): Impact on Gastrointestinal Absorption." View this on SpringerLink >

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Ho-Leung Fung Ph.D., FAAPS
Editor-in-Chief
University at Buffalo
Buffalo NY
[email protected]

Disclaimer: Opinions expressed are solely my own and do not express the views or opinions of my employer.
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