We published recently on in vitro assay for man immunogenicity. Please see this link if you are interested
A mechanistic marker-based screening tool to predict clinical immunogenicity of biologics - Communications Medicine
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| A mechanistic marker-based screening tool to predict clinical immunogenicity of biologics - Communications Medicine |
| Jarvi and Balu-Iyer evaluate an immunogenicity screening toolbox in which in vitro assays capture the migratory potential of dendritic cells. Expression of the chemokine receptor CXCR4 on dendritic cells and their migration toward chemokines CCL21 and CXCL12 in the presence of therapeutic protein correlates with their clinical immunogenicity. |
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Sathy Balu-Iyer Ph.D., FAAPS
Professor and Associate Dean for Research
SUNY - University At Buffalo
Buffalo NY
[email protected]Disclaimer: Opinions expressed are solely my own and do not express the views or opinions of my employer.
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Original Message:
Sent: 12-09-2024 14:20
From: Robert Nelson
Subject: in vitro immunogenicity assays
Hi Cedric,
There looks to be a number of presentations on different approaches for in vitro and in vivo assessment of immunogenicity potential at the EIP Symposium in February 2025: EIP | 2025 Lisbon
Hopefully other can share their thoughts here (I think your original post landed around the Thanksgiving break...)
Regards,
Rob
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Robert Nelson
Scientific Officer, Senior Director
BioAgilytix Europe GmbH
Hamburg Germany
[email protected]
Disclaimer: Opinions expressed are solely my own and do not express the views or opinions of my employer or other entities to which I am affiliated.
Original Message:
Sent: 11-25-2024 05:01
From: Cedric Cortijo
Subject: in vitro immunogenicity assays
Hello,
We are exploring in vitro immunogenicity assays for ranking and de-risking human-derived monoclonal antibody candidates. Has anyone had any relevant experience with such assays offered by ProImmune? If so, we would appreciate any feedback. If you have recommendations for other providers, please do not hesitate.
Thank you so much for your feedback.
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Cedric Cortijo
Head of Bioanalytics
Neurimmune AG
Schlieren
[email protected]
Disclaimer: Opinions expressed are solely my own and do not express the views or opinions of my employer.
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