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Dear colleagues,
Traditionally, drug release from submicron emulsions has been assessed using two primary techniques: dialysis (drug-emulsion mixture in a dialysis bag) and reverse dialysis (drug-emulsion in bulk medium). Levy and Benita (1990) demonstrated that both methods yielded comparable drug release profiles for diazepam emulsions.
Given this background, which technique would be considered most appropriate and scientifically robust for evaluating the in vitro performance of oral oil-in-water (O/W) emulsions containing BCS Class II drugs?
I look forward to your insights and recommendations.
Best regards.