Join the Immunogenicity Discussion Group (IDG) this Wednesday June 4th @ 12-13h EDT (18-19h CEST).
We will host Alexander Pöhler from Roche, who will discuss work that was recently published in the AAPS Journal – A Tool to Eliminate IgM Immunoassay Interference (https://doi.org/10.1208/s12248-025-01067-0)
Abstract
IgM-selective proteolytic cleavage can become a groundbreaking tool for immunoassay-based bioanalysis. We tested the utility of a newly introduced IgM-selective protease in three different bioanalytical applications and showed that protease treatment can eliminate rheumatoid factor interference and simplify IgM isotyping. Surprisingly, we discovered that a gene therapy-induced immune response was underestimated in an anti-capsid IgG assay when treatment-emergent IgM were present in the matrix. Selective IgM digestion eliminated this interference.
Connection details are below, or an iCal invitation attached.
Rob & Todd
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Robert Nelson
Scientific Officer
BioAgilytix Laboratories
[email protected]Disclaimer: Opinions expressed are solely my own and do not express the views or opinions of my employer or other entities to which I am affiliated.
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