Have you ever wondered how to evaluate food effect during drug product development, and how this can affect the overall exposure of the drug in a general population?
Check out this literature review recently published in the AAPS journal Gastrointestinal Bile Salt Concentrations in Healthy Adults Under Fasted and Fed Conditions: A Systematic Review and Meta-Analysis for Mechanistic Physiologically-Based Pharmacokinetic (PBPK) Modelling | The AAPS Journal
"The findings from this meta-analysis can be used for the purpose of PBPK modelling to capture segmental drug solubilisation and absorption in fasted and fed states."
Tell us more, what challenges have you faced when evaluating food effect using PBPK modelling?
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Maiara Montanha Pharm.D., Ph.D.
Biopharmaceutics Principal Scientist
Bristol-Myers Squibb
United Kingdom
Disclaimer: Opinions expressed are solely my own and do not express the views or opinions of my employer.
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