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  • 1.  FDA doesn't appeal decision to vacate LDT Final Rule

    Posted 06-03-2025 13:23

    On Friday or Saturday - depending on who your read - the FDA did not file an appeal to challenge to the Texas District Court decision to vacate the LDT Final Rule. That means the Final Rule is dead as written. Lots of articles out there on the topic - here are just three:

    https://www.ascp.org/news/news-details/2025/06/02/the-ldt-final-rule-is-officially-dead--fda-has-no-jurisdiction

    https://www.medtechdive.com/news/FDA-declines-appeal-lab-developed-tests-LDTs-ruling/749667/

    https://news.bloomberglaw.com/health-law-and-business/fda-skips-move-to-revive-suit-over-agencys-lab-test-authority

     #fda #LDT #FinalRuleVacated



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    Mark Arnold Ph.D., FAAPS
    Westampton, NJ
    [email protected]
    Bioanalytical Solution Integration
    LinkedIn: https://www.linkedin.com/in/markearnoldphd/
    Website & Blog: Bioanalysis & Biomarkers <bioanalysisandbiomarkers.blogspot.com>
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    </bioanalysisandbiomarkers.blogspot.com>


  • 2.  RE: FDA doesn't appeal decision to vacate LDT Final Rule

    Community Leadership
    Posted 06-04-2025 13:00

    I suspected they wouldn't. This may shift some more global programs to exclude EU from earlier trials to avoid the IVDR, but I would expect the desire to work with European doctors and PIs would minimize that impact.



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    Joleen White Ph.D.
    AAPS 2024 Global Health Community Chair
    Bioanalytical 101 Course Development
    Senior Advisor
    BioData Solutions LLC
    [email protected]

    Disclaimer: Opinions expressed are solely my own and do not express the views or opinions of my employer.
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  • 3.  RE: FDA doesn't appeal decision to vacate LDT Final Rule

    Past President
    Posted 06-04-2025 19:25

    Mark 

    Are we able to put a programming in place to discuss this topic at AAPS.

    Binodh



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    Binodh DeSilva Ph.D.
    Senior Vice President
    Ultragenyx
    Skillman NJ
    [email protected]

    Disclaimer: Opinions expressed are solely my own and do not express the views or opinions of my employer.
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  • 4.  RE: FDA doesn't appeal decision to vacate LDT Final Rule

    Posted 06-04-2025 20:32

    Binodh,

    I'm not on this year's SPC or RFC to know if the topic has already been submitted, but the only option left is for a Rapid Fire and the deadline is 16June. Perhaps the BioA and Biomark & Precision Medicine Communities will work together on something.

    Regards,

    Mark



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    Mark Arnold Ph.D., FAAPS
    Westampton, NJ
    [email protected]
    Bioanalytical Solution Integration
    LinkedIn: https://www.linkedin.com/in/markearnoldphd/
    Website & Blog: Bioanalysis & Biomarkers <bioanalysisandbiomarkers.blogspot.com>
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  • 5.  RE: FDA doesn't appeal decision to vacate LDT Final Rule

    Community Leadership
    Posted 06-05-2025 13:04

    I am also not aware that this topic has been submitted for PharmSci360.  If not, there is interest from the BPM community to collaborate with BA to pull a proposal together.



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    Karen Quadrini, PhD
    Director, Clinical Biomarkers
    Prothena Biosciences
    Brisbane, CA
    [email protected]

    Disclaimer: Opinions expressed are solely my own and do not express the views or opinions of my employer.
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  • 6.  RE: FDA doesn't appeal decision to vacate LDT Final Rule

    Past President
    Posted 06-05-2025 13:48

    Karen, Mark we should try to see if we can pull a program together.  We may not have sufficient information but at least we can start the conversation and then move to a full program for next year.



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    Binodh DeSilva Ph.D.
    Senior Vice President
    Ultragenyx
    Skillman NJ
    [email protected]

    Disclaimer: Opinions expressed are solely my own and do not express the views or opinions of my employer.
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  • 7.  RE: FDA doesn't appeal decision to vacate LDT Final Rule

    Community Leadership
    Posted 06-06-2025 15:41

    Binodh, yes we should form a small team to move this forward. If anyone from the BA community is interested in joining this team, please reach out.  There are a couple of interested BPM community members that have volunteered already.  



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    Karen Quadrini, PhD
    Director, Clinical Biomarkers
    Prothena Biosciences
    Brisbane, CA
    [email protected]

    Disclaimer: Opinions expressed are solely my own and do not express the views or opinions of my employer.
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