The issue with R - like all the relatively new open-source SW - is that you need a strong and centralized consortium to establish which algorithms are most solid and how the validation & verification should be carried out. One may argue that building with MATLAB might have a similar issue, however we all trust ODE solver and fitting algorithms there. I am not saying that R is untrustworthy, on the contrary, there can be more sparkle for innovation there, but it is you add an additional layer of checks and getting together to establish standards. Maybe we will get there, so it is with investing time now and Academia should do carry the load.
On the other hand, established sw are more convenient considering the time-cost ratio you'll have in the long run.
Another point, and perhaps a myth, is that there is no software that does everything great from preclinic to the clinic to market!
For a list of software refer to:
https://www.page-meeting.org/default.asp?alias=912My humble opinion is (depends on the area of modeling you want to do though):
>PK & popPK>: Phoenix/Nonmem/monolix
>PBPK> simcyp/pk sim(free)/gastroplus
>complex PK/PD > SAAM II
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Simone Perazzolo
Scientist
University of Washington
SOUTHAMPTON
[email protected]Disclaimer: Opinions expressed are solely my own and do not express the views or opinions of my employer.
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Original Message:
Sent: 11-20-2022 14:53
From: Ahmed Adel
Subject: Computing Language for PK/PD.
Hello dear Colleges, I believe that R is the most commonly used language for PK/PD outcomes computing. that what I were able to reach through my search till now. would you agree to that. if yes. is there a way to learn the use of the computing program on my own?
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Ahmed Adel
Pharmaceutical Scientist, CCRP
Cur-is Life Sceinces Solutions®
Duesseldorf
[email protected]
Disclaimer: Opinions expressed are solely my own and do not express the views or opinions of my employer.
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