To promote the discussion, I capture several notes below:
Volumetric absorptive microsampling (VAMS) is a promising technique for pharmacokinetic (PK) studies, but it does come with some challenges that need to be addressed.
- Sample handling and preservation: VAMS samples are typically stored at room temperature, but this can lead to potential degradation or alteration of the samples, which can affect the accuracy of the PK data.
- Not all laboratories have the equipment to analyze VAMS samples, and there are currently no established standards for handling and analyzing VAMS samples.
- Since VAMS samples are collected in small volumes, the precision and accuracy of the PK data obtained from the samples may be lower than that obtained from traditional methods.
- Comparison to traditional methods: VAMS method is not yet widely accepted.
- The regulatory perspectives on VAMS are unclear.
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Mark Ma Ph.D.
Exe. Director
Alexion Pharma
New Haven CT
[email protected]Disclaimer: Opinions expressed are solely my own and do not express the views or opinions of my employer.
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