Thanks for posting about this important topic on lipid nanoparticles (LNP) for mRNA vaccines. A recent review article from Dan Peer's group has elaborated on the major issues and potential solutions (Sharma P, Hoorn D, Aitha A, Breier D, Peer D. The immunostimulatory nature of mRNA lipid nanoparticles. Advanced Drug Delivery Reviews. 2024 Jan 11:115175).
Once the mRNA design is optimized, the lipid design becomes crucial. Decisions such as the impact of PEG, and the cationic and ionizable lipids etc. significantly influence cellular uptake. At the preclinical level, one of the major concerns is undesirable immunostimulation, which may be due to the adjuvant effect of the lipids.
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Sudip Das, MPharm, PhD
Distinguished Faculty, Butler University
Professor of Pharmaceutics & Drug Delivery
4600 Sunset Avenue, Indianapolis, IN 46208-3485
E-mail:
[email protected]Webpage:
https://research.butler.edu/nanomedicine/LinkedIn:
http://www.linkedin.com/in/sudipkdasDisclaimer: Opinions expressed are solely my own and do not express the views or opinions of my employer.
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Original Message:
Sent: 07-02-2024 22:35
From: Dimple Modi
Subject: Advancements in mRNA vaccine delivery
What are the latest advancements in lipid nanoparticle technology for mRNA vaccine delivery? Could you please share your experience or related research paper you come across?
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Dimple Modi
Investigator
GlaxoSmithKline
Gilbertsville PA
[email protected]
Disclaimer: Opinions expressed are solely my own and do not express the views or opinions of my employer.
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