Webinar: Wednesday, 27 March 2024 12:00 PM EST
"Generation of Exosome Mimetics for Bone Regeneration"
Jiabing Fan, MD, PhD.
Assistant Professor, Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland Eastern Shore, MD
Abstract: Exosomes, derived from mesenchymal stem cells (MSCs), show great promise in drug and gene delivery, as well as in disease diagnosis and treatment. Notably, the exosome-mediated approach has gained attention in the field of bone repair and regeneration. However, challenges such as low production yield, limited efficacy of external drug carriers, and unpredictable therapeutic outcomes of exosomes have impeded their widespread clinical application. Here, we introduce an innovative strategy involving the production of exosome-related vesicles termed exosome mimetics (EMs) with remarkably high yields. Additionally, we employ engineering approaches to enhance the effectiveness of EMs in drug and gene delivery, as well as improve therapeutic outcomes. Our work highlights the significant potential of engineered EMs in the realms of tissue regeneration and cell-free therapy.
Registration:
https://umaryland.zoom.us/meeting/register/tJUqce6rpj4pHN0fKVwcJ5gIfN5VWhfCGNwk
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Robert D. Arnold, Ph.D. "Rusty"
Professor, Director of Research Support & Development
Department of Drug Discovery & Development
Auburn University, Harrison College of Pharmacy
Auburn, AL 36849 U.S.A.
Email:
[email protected]Office: (334) 844-8434
Disclaimer: Opinions expressed are solely my own and do not express the views or opinions of my employer.
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