AAPS-LBDDS Webinar Invitation

(Jointly hosted by LBDDS, Nanotech and Modified Release Communities)

Hydrophobic Ion Pairing in Self-emulsifying System: Drug Loading and Precipitation Kinetics

Dr. Ketan Patel, Associate Professor of Pharmaceutical Sciences, St. John’s University, New York, NY.

Self-nanoemulsifying system is one of the simplest yet versatile drug delivery platforms for lipophilic drug molecules. In pursuit of developing molecules targeting “undruggable” proteins, the majority of the novel class of anticancer molecules are poorly water-soluble molecules falling in the Extended rule of 5 (ERo5) or Extended rule of 5 (BRo5) space. Poor drug loading in self-emulsifying preconcentrate and rapid precipitation in contact with an aqueous milieu are the key factors limiting the translational potential of lipid-based systems. The webinar will cover the current challenges in lipid-based drug delivery systems and the role of the hydrophobic ion pairing approach in enhancing drug loading as well as minimizing precipitation in the aqueous phase.

August 08, 2024, 12:00 to 1:30 pm Eastern Time (US and Canada)

Register: https://learning.aaps.org/topclass/topclass.do?expand-OfferingDetails-Offeringid=310654

The American Association of Pharmaceutical Scientists (AAPS)-Modified Release Community (MRC) Webinar Invitation.
(Jointly hosted by AAPS Nanotech Community)

Kevin McHugh, PhD, Assistant Professor, Departments of Bioengineering & Chemistry, Rice University
"Biodegradable microstructures and dynamic covalent bonding as tools for controlling the release of small-molecule and protein drugs"

Webinar: Monday, 17 June 2024, 12-1:00 PM Eastern Time

Seminar summary:
Drugs have revolutionized modern healthcare, reducing mortality and morbidity for many diseases. As a result, more than half of the world’s population takes at least one medication every day. However, despite their enormous health benefits, drug utility is limited by sub-optimal efficacy, side effects, low patient adherence, and accessibility issues. This seminar will describe the development of two drug delivery platforms - one based on a self-assembled peptide hydrogel and another based on microfabricated polymeric particles. These systems are capable of modulating the timing and location of drug release via different mechanisms, which can be optimized for the disease of interest. In the first system, self-assembled peptides functionalized to engage in dynamic covalent bonding are shown to prolong small-molecule and protein therapeutic release, thereby improving pharmacokinetic profiles and drug efficacy in both diabetes and tuberculosis. In the second system, microparticles with core-shell structures are shown to exhibit pulsatile drug release after a delay that can be tuned from hours to months. Then, by combining different particle populations, full dosing regimens can be administered in a single injection. This approach is particularly attractive for use in the development of single-injection vaccines that can improve access to immunization in low-resource settings.

Best,

Vibhuti Agrahari

MRC Community